Daily Cleanse: An Antioxidant & Anti-Inflammatory Agent

September 27, 2021

Daily Cleanse: An Antioxidant & Anti-Inflammatory Agent

Some things in life are simply unavoidable, including exposure to harmful toxins, free radicals, acute or chronic inflammation, and oxidative stress. Toxins and free radicals are primarily produced within the body from metabolism, but they are also found in nature and can be made synthetically. Inflammation on the other hand can be a result of numerous factors, including exercise, injury, and disease.

Although you can limit your exposure to toxins, free radicals, and oxidative stressors, there’s no way to completely escape their negative effects on health and performance. What’s more, inflammation can be healthy in specific contexts, however chronic inflammation can also take a toll on your health, performance, and ability to recover.

In order to combat toxins, free radicals, inflammation, and oxidative stress, it’s no surprise that your body has developed its very own detoxification system. Your body’s internal detoxification system consists of various organs, each with their own unique functions, including the lungs, skin, kidneys, liver, stomach, small intestine, and large intestine. Even though your body performs detoxification on its own, that doesn’t mean it can’t benefit from the help of external factors, such as supplements.

We are well aware that there are hundreds, if not thousands, of “detox” supplements available. However, the vast majority of them contain low-quality ingredients that are underdosed, underresearched, and therefore, not effective. Instead of adding another terrible product to the detox category, we took a completely different approach by creating a supplement that’s fully transparent, efficaciously dosed, and extremely effective!

Allow us to introduce you to Daily Cleanse!!

Daily Cleanse: Your New Secret Weapon

Since years of training and hard work can increase your body’s susceptibility to injury, fatigue, and simply wear & tear, we’ve developed a complete detox, antioxidant, and anti-inflammatory agent to help you keep healthy from the inside out.

Key features:

  • Fully disclosed label
  • 3 patented/trademarked ingredients
  • 30-day supply
  • Vegan-friendly
  • Soy-free
  • Gluten-free
  • Keto-friendly
  • Third-party tested
  • Made in a GMP-certified & FDA Registered/Inspected Manufacturing Facility

Ingredient Breakdown

Here’s what one serving (4 capsules) of Daily Cleanse contains:

L-Glutathione - 250mg

Glutathione is a tripeptide molecule that’s composed of three different amino acids, cysteine, glutamic acid, and glycine. Glutathione is found in most cells throughout the body and plays an important role in detoxification, immune system function, and protecting healthy cells against oxidative stress.[1]

Some of the key bodily functions that glutathione assists with include:

  • Direct chemical neutralization of singlet oxygen, hydroxyl radicals, and superoxide radicals
  • Cofactor for several antioxidant enzymes
  • Regeneration of vitamins C and E
  • Neutralization of free radicals produced by Phase I liver metabolism of chemical toxins
  • Transportation of mercury out of cells and the brain
  • Regulation of cellular proliferation and apoptosis
  • Vital to mitochondrial function and maintenance of mitochondrial DNA (mtDNA)[1]

As you can see, having an adequate amount of glutathione is critical for overall health. Since glutathione is one of the most powerful antioxidants and anti-inflammatory molecules, we made sure to include it in Daily Cleanse!

Artichoke Powder - 250mg

Artichoke is a vegetable that’s chock-full of nutrients and offers a variety of health benefits, including reducing blood sugar levels, promoting digestion, and supporting both heart & liver health.[2-4] However, artichoke extract is a much more concentrated version of the plant that’s often used in supplements.

In fact, artichoke is considered to be one of the most antioxidant rich vegetables in the world. Antioxidants help scavenge free radicals, manage inflammation, support the immune system, and protect against oxidative stress. Studies have shown that artichoke may help lower cholesterol levels, regulate blood pressure, promote liver health, improve digestive health, and lower blood glucose levels.[2-4]

Dandelion Extract - 250mg

Dandelion extract is a herb that possesses several medicinal properties, including antioxidant, anti-inflammatory, hypoglycemic, diuretic, and anti-rheumatic.[5-8] Traditionally, dandelion has been utilized as a natural diuretic, to support liver & kidney function, aid digestion, and defend against oxidative stress induced by free radicals.[5-8]

Dandelion’s benefits are attributed to it’s robust phytochemistry, which includes caffeic acid, taraxasterol, ixerine, chicoric acid, taraxinic acid, and chlorogenic acids.[5,6] Each of these bioactive compounds have their own unique benefits. We primarily included dandelion extract in Daily Cleanse to help get rid of excess water, while simultaneously supporting optimal electrolyte balance.

Milk Thistle Powder - 250mg

Milk thistle, also known as Silybum marianum, is a plant that grows bright purple flowers, yet is incredibly rich in a biologically active compound called silymarin. Silymarin possesses powerful antiviral, antioxidant, and anti-inflammatory properties.[9] Silymarin has the ability to reduce free radical production and lipid peroxidation, while inhibiting the binding of toxins to the cell membranes of hepatocytes.[9]

Milk thistle is most well known for its hepatoprotective properties, which means it helps protect the liver against damage caused by various medical conditions, such as hepatitis, alcoholic liver disease, and nonalcoholic fatty liver disease.[9] What’s more, milk thistle also supports brain health, bone density, and may help lower blood sugar levels.[10-12]

Beet Root Powder - 250mg

Beet root is naturally rich in nitrates, a chemical compound that gets converted into nitric oxide within the body.[13] Increased levels of nitric oxide cause vasodilation (expansion) of the blood vessels, which is advantageous for nutrient & oxygen delivery, as well as overall cardiovascular health.[13]

Beet root is also rich in several other bioactive constituents, such as ascorbic acid, flavonoids, carotenoids, betalains, and phenolic acids, which provide numerous other health benefits.[13] Betalains in particular, express potent anti-inflammatory and antioxidant properties.[13] Therefore, they may play a role in reducing inflammation associated with various health ailments.[13]

White Willow Bark Extract - 150mg

White willow bark extract is commonly referred to as “nature’s aspirin” because it seems to have the ability to reduce inflammation and pain.[14] White willow bark has a long history of use as an anti-inflammatory, analgesic, and antipyretic agent.[14]

White willow bark’s pain-relieving properties are primarily attributed to it’s salicin content.[14] However, white willow bark also contains several other biologically active compounds that further contribute to its effects, such as polyphenols and flavonoids.[14]

Furthermore, there seems to be less adverse effects associated with white willow bark as opposed to other non-steroid anti-inflammatory medications.[14]

Burdock Powder - 125mg

Burdock root is a vegetable that’s typically found growing in parts of Europe, Asia, and more recently, the United States. Burdock has been used for centuries in Traditional Chinese Medicinal practices however it’s most commonly utilized as a digestive aid and diuretic.[15]

With further research, it turns out that burdock has a lot more health benefits to offer beyond just serving as a digestive aid and natural diuretic. Burdock contains a robust amount of antioxidants, including luteolin, quercetin, and phenolic acids.[15]

Furthermore, some preliminary studies suggest that burdock assists in the removal of toxins from the body and promotes blood flow to the skin, which may improve the appearance of skin.[15]

Grape Seed Extract - 125mg

Grape seed extract (GSE) is a rich source of antioxidants, such as flavonoids, anthocyanins, and phenolic acids.[16] However, grape seed extract is most well known for its proanthocyanidin content, because compared to other foods, it ranks among the highest.[16]

The grape seed extract that we use in Daily Cleanse is actually standardized to contain at least 95% proanthocyanidins, so you know you’re getting the maximum benefit that this biologically active compound has to offer. Due to it’s high amount of antioxidants, grape seed extract packs a host of health benefits.[17]

Supplementing with grape seed extract may be able to assist in the reduction of inflammation, promote recovery, and lower oxidative stress.[17] Several studies have shown that grape seed extract supports healthy blood pressure, cholesterol levels, liver, kidney, and brain function, and may even promote blood flow.[17-22]

Curcumin C3 Complex® - 100mg

Instead of using generic curcumin or turmeric root powder, Daily Cleanse features a patented form of curcmin, known as Curcumin C3 Complex®.[23] Curcumin C3 Complex® comes from Sabinsa Corporation, one of the leading ingredient suppliers in the dietary supplement industry.[23]

As the name suggests, Curcumin C3 Complex® consists of 3 highly biologically active curcuminoids, including curcumin, demethoxycurcumin, and bisdemethoxycurcumin.

Curcumin C3 Complex® is derived from the dried rhizomes of Curcuma longa, also known as turmeric, and is standardized to contain at least 95% curcuminoids.[23] Although curcumin offers numerous health benefits, it’s most commonly used as an anti-inflammatory agent.[23]

Alpha Lipoic Acid - 100mg

Alpha lipoic acid (ALA) is an organic compound that’s naturally produced by the body and found in several foods. Alpha lipoic acid is primarily produced in the mitochondria, which is where the majority of energy production takes place (in the form of adenosine triphosphate). Alpha lipoic acid acts as a powerful antioxidant, therefore it may help protect cells from oxidative stress induced by free radicals.

One unique feature of alpha lipoic acid is that it’s both fat and water soluble, so it can act upon nearly any and every cell throughout the body. Due to ALA’s powerful antioxidant properties, it’s been shown to assist with the reduction of inflammation.[24] Although various foods contain ALA, it’s likely more beneficial to supplement with it since you would have to eat a large quantity of specific foods in order to get enough.

Spectra™ - 100mg

According to FutureCeuticals, “Spectra™ is a plant-based, scientifically validated formula of 29 fruits, vegetables, and herbs shown to reduce free radical production & optimize cellular metabolic activity within the human body.”[25]

Spectra consists of the following fruits, vegetables, and herbs:

  • Coffea arabica
  • Green tea
  • Broccoli sprout
  • Onion
  • Apple
  • Quercetin
  • Tomato
  • Broccoli
  • Camu Camu
  • Acerola
  • Acai
  • Turmeric
  • Garlic
  • Basil
  • Oregano
  • Cinnamon
  • Carrot
  • Elderberry
  • Mangosteen
  • Blackcurrant
  • Blueberry
  • Sweet cherry
  • Raspberry
  • Spinach
  • Chokeberry
  • Kale
  • Blackberry
  • Bilberry
  • Brussels sprout

Furthermore, Spectra™ targets all 5 primary types of free radicals in the body, therefore it’s considered to be a full-spectrum antioxidant.[25] The clinically studied dose of Spectra™ is 100 milligrams, which is exactly what’s included in every serving of Daily Cleanse![25]

The primary benefits of Spectra™ include:

  • Stimulates antioxidant activity within the human body
  • Inhibits free radicals
  • Supports efficient cellular oxygen consumption 
  • Optimizes cellular metabolism
  • Supports a healthy immune response[25]

L-Methionine - 50mg

Methionine is one of the few sulfur containing essential amino acids that’s naturally found in various foods, such as dairy, meat, and fish. Since methionine is deemed as an essential amino acid, it cannot be adequately produced by the body, therefore it must be obtained through diet and/or supplementation.[26]

Methionine takes on many different roles in the human body, however, its most notably used for the production of cysteine and taurine. Cysteine is a conditionally essential amino acid that’s needed for the synthesis of glutathione, the most powerful antioxidant in the body.[26]

Taurine is also classified as a conditionally essential amino acid and it also contributes to numerous bodily functions, such as the formation of bile salts, maintenance of proper hydration and electrolyte balance in cells, calcium regulation, nervous system function, eye function, and immune system health.[26]

Methionine is also converted into S-adenosylmethionine (SAM), a molecule that helps reduce levels of homocysteine and support the production of creatine.[26]

Bioperine® - 5mg

The final active ingredient in Daily Cleanse is Bioperine®, a patented black pepper extract that’s standardized to contain at least 95% piperine.[27] Bioperine® doesn't have a ton of benefits on its own, but when combined with other ingredients, such as curcumin, it significantly increases the absorption and bioavailability of various dietary ingredients.[27]

Through various mechanisms, Bioperine® increases the overall effectiveness of a product by increasing the body’s ability to absorb and utilize the ingredients.[27] Since Daily Cleanse has curcumin, which is poorly absorbed on its own, we made sure you were getting the most from this supplement by adding in a solid dose of Bioperine®.[27]

If you’re familiar with any of our supplements, especially the capsule-based ones, you already know that we are huge proponents of Bioperine®. And now you know why!

Other Ingredients

The following ingredients are used in minuscule amounts to make the capsule or assist with the manufacturing process of Daily Cleanse:

  • Vegetable cellulose - capsule
  • Microcrystalline - excipient
  • Magnesium stearate - flow agent

Suggested Use

For optimal results, take 4 capsules daily with 8-10 ounces of water. You can also implement split dosing by taking 2 capsules in the morning and two capsules later in the day. Daily Cleanse can be taken any time of the day and with or without food.

Stacking Options

Daily Cleanse stacks well with the following supplements:

  • Multivitamin: comprehensive vitamin and mineral supplement
  • Omega-3: high-potency EPA & DHA supplement
  • CLA: high-quality conjugated linoleic supplement
  • Elbow Grease: joint health support supplement

Feel 100% From the Inside Out with Daily Cleanse

Unlike a pre-workout, nootropic, or energy drink, Daily Cleanse takes some time before you really start feeling its effects. But, after a few weeks, you should start to notice naturally higher energy levels, better mood, improved digestion, and a host of other health benefits.

As the name suggests, it’s important to take Daily Cleanse every single day. If you only take it once in a while, then don’t expect to get any of the benefits it has to offer. Combined with proper hydration, adequate sleep, a sound nutrition plan, and exercise, Daily Cleanse will have you feeling 100% from the inside out.

References

  1. Pizzorno, J. Feb. 2014. “Glutathione!” Integrative Medicine: A Clinician's Journal, vol. 13(1): 8-12.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684116/
  2. Sahebkar, A. et al. Aug. 2018. “Lipid-Lowering Activity of Artichoke Extracts: A Systematic Review and Meta-Analysis.” Critical Reviews in Food Science and Nutrition, vol. 58(15): 2549-56.https://pubmed.ncbi.nlm.nih.gov/28609140/
  3. Roghani-Dehkordi F & Kamkhah AF. 2009. “Artichoke Leaf Juice Contains Antihypertensive Effect in Patients with Mild Hypertension.” Journal of Dietary Supplements, vol.6(4):328-41.https://pubmed.ncbi.nlm.nih.gov/22435514/
  4. Ben Salem M. et al. Dec. 2015. “Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits.” Plant Foods For Human Nutrition, vol. 70(4):441-53.https://pubmed.ncbi.nlm.nih.gov/26310198/
  5. Wirngo, F. et al. Aug. 2016. “The Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes.” The Review of Diabetic Studies vol. 13,3.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553762/
  6. Clare, B. et al. Aug. 2009. “The Diuretic Effect in Human Subjects of an Extract of Taraxacum officinale Folium over a Single Day.” Journal of Alternative and Complementary Medicine vol. 15, 8; 929-34.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155102/
  7. Yousefi G. et al. Apr. 2018. “Inhibitory Effects of Taraxasterol and Aqueous Extract of Taraxacum Officinale on Calcium Oxalate Crystallization: In Vitro Study;” Renal Failure vol. 40,1; 298-305.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014465/
  8. Cai, L. et al. July 2017. “Purification, Preliminary Characterization and Hepatoprotective Effects of Polysaccharides from Dandelion Root.” Molecules vol. 22,9; 1409.https://www.mdpi.com/1420-3049/22/9/1409/htm
  9. Abenavoli L et al. Oct. 2010. “Milk Thistle in Liver Diseases: Past, Present, Future.” Phytotherapy Research, vol. 24(10):1423-32.https://pubmed.ncbi.nlm.nih.gov/20564545/
  10. Devi KP, et al. 2017. “A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin.” Current Drug Targets, vol. 18(13):1529-36.https://pubmed.ncbi.nlm.nih.gov/28025940/
  11. Mohd Fozi NF et al. Dec. 2013. “Milk Thistle: A Future Potential Anti-Osteoporotic and Fracture Healing Agent.” Current Drug Targets, vol. 14(14):1659-66.https://pubmed.ncbi.nlm.nih.gov/24093748/
  12. Voroneanu L, et al. June 2016. “Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.” Journal of Diabetes Research, vol. 2016.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908257/
  13. Clifford, T et al. April 2015. “The Potential Benefits of Red Beetroot Supplementation in Health and Disease.” Nutrients, vol. 7(4), 2801–22.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425174/
  14. Shara M et al. Aug. 2015. “Efficacy and Safety of White Willow Bark (Salix alba) Extracts.” Phytotherapy Research, vol. 29(8):1112-6.https://pubmed.ncbi.nlm.nih.gov/25997859/
  15. Chan, YS. et al. Oct. 2010. “A Review of the Pharmacological Effects of Arctium lappa (burdock). Inflammopharmacology, vol. 19, 245–54.https://link.springer.com/article/10.1007/s10787-010-0062-4
  16. Ma, Z et al. Sept. 2017. “Phytochemical Constituents, Health Benefits, and Industrial Applications of Grape Seeds: A Mini-Review.” Antioxidants, vol. 6(3), 71.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618099/
  17. Cádiz-Gurrea, M. et al. Feb. 2017. “Cocoa and Grape Seed Byproducts as a Source of Antioxidant and Anti-Inflammatory Proanthocyanidins.” International Journal of Molecular Sciences, vol. 18(2), 376.https://pubmed.ncbi.nlm.nih.gov/28208630/
  18. Zhang, H et al. Aug. 2016. “The Impact Of Grape Seed Extract Treatment On Blood Pressure Changes: A Meta-analysis Of 16 Randomized Controlled Trials.” Medicine vol. 95,33: e4247.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370781/
  19. Shenoy, S. et al. Oct. 2007. “Effects Of Grape Seed Extract Consumption On Platelet Function In Postmenopausal Women.” Thrombosis Research, vol. 121(3), 431–432.https://pubmed.ncbi.nlm.nih.gov/17950783/
  20. Calapai, G. et al. Oct. 2017. “A Randomized, Double-Blinded, Clinical Trial on Effects of a Vitis vinifera Extract on Cognitive Function in Healthy Older Adults.” Frontiers in Pharmacology, 8, 776.https://pubmed.ncbi.nlm.nih.gov/29163162/
  21. Turki, K. et al. June, 2016. “Grape Seed Powder Improves Renal Failure Of Chronic Kidney Disease Patients.” EXCLI Journal, vol. 15, 424–33.https://pubmed.ncbi.nlm.nih.gov/27822171/
  22. Khoshbaten, M., et al. July 2010. “Grape Seed Extract To Improve Liver Function In Patients With Nonalcoholic Fatty Liver Change.” Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association, vol. 16(3), 194–97.https://pubmed.ncbi.nlm.nih.gov/20616415/
  23. Sabinsa Corporation, Aug. 2021. “Curcumin C3 Complex®.”https://curcuminoids.com/introduction
  24. Saboori, S. et al. Aug. 2018. “Effects of Alpha-Lipoic Acid Supplementation on C-Reactive Protein Level: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.” Nutrition, Metabolism, and Cardiovascular Diseases, vol. 28(8),  779-86.https://www.sciencedirect.com/science/article/abs/pii/S0939475318301248
  25. FutureCeuticals. Accessed August 2021. “Spectra™.”https://www.futureceuticals.com/spectra
  26. Bronson, JT & Bronson, ME. June 2006. “The Sulfur Containing Amino Acids: An Overview.” The Journal of Nutrition, vol. 136(6): 1636S-1640S.https://academic.oup.com/jn/article/136/6/1636S/4664439
  27. Sabinsa Corporation. Accessed August 2021. “Bioperine®: Black Pepper Extract.” https://bioperine.com/aboutbioperine/black-pepper-extract/

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